Driving long distances is FUN.
I drove from Frederick, MD to Lafayette LA, (nearly 1300 miles) in 15 hours. Stopped 3 times for gas, thats it.
I-95 is nasty in VA, other than that, you are good to go. Rt. 81 is worse, thats the other route south towards AL/GA/LA
I drive through TN at 110-120, and AL at 100, GA 120, LA 75 (the causeway is crawling with cops now